Across TCGA pan-cancer cohorts, BPIFC RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of BPIFC’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BPIFC RNA is repressed in tumor relative to normal tissue. In most cancer types BPIFC is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
KIRC, KICH, and THCA are the cancer types where BPIFC tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BPIFC RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.