BPIFB6

Across TCGA patient cohorts, BPIFB6 mutation is significantly associated with the RNA expression of many other genes, with 1,306 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPIFB6-associated genes across cancer lineages are ALAS1, KNSTRN, and LINC02438. Each is linked with BPIFB6 in more than 2 cancer types. Because this analysis shows association rather than direction, both BPIFB6-to-partner and partner-to-BPIFB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALAS1 grouped by BPIFB6-low versus BPIFB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPIFB6→partner) and Y-score (partner→BPIFB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ALAS1 →	+0.742	+2.592	<.001	.006	3	3
COAD	KNSTRN →	+0.474	+3.342	.005	.005	3	3
UCEC	LINC02438 →	+0.603	+3.346	.001	.005	3	3
BRCA	RNA5SP414 →	+0.216	+8.471	<.001	.005	3	2
UCEC	VPS37A →	+0.595	+2.818	.002	.001	3	2
UCEC	CCNB2 →	+0.865	+2.807	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,306 associations by consensus.

ALAS1 by BPIFB6 expression — UCEC

Explore this box plot interactively →