BPIFB6

Across TCGA pan-cancer cohorts, BPIFB6 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of BPIFB6’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where BPIFB6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BPIFB6 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

BRCA, HNSC, and KIRC are the cancer types where BPIFB6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BPIFB6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	+0.112	.001	6	view →
HNSC	All	All	−0.358	.003	5	view →
KIRC	Female	All	+0.014	.035	2	view →
LUAD	Female	All	+0.016	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

BPIFB6–BRCA

Open the BRCA breakdown →