BPIFB6

Across TCGA patient cohorts, BPIFB6 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPIFB6-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, Bak, and PDCD4. Each is linked with BPIFB6 in more than 2 cancer types. Because this analysis shows association rather than direction, both BPIFB6-to-partner and partner-to-BPIFB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by BPIFB6-low versus BPIFB6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPIFB6→partner) and Y-score (partner→BPIFB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.521	+2.817	.033	.036	3	3
UCEC	Bak →	+0.306	+2.459	.011	.020	3	3
UCEC	PDCD4 →	-0.667	-2.459	.003	.020	3	2
COAD	Shc_pY317 →	-0.190	-2.313	.012	.035	3	2
SKCM	14-3-3_epsilon →	+0.149	+2.824	.043	.036	3	2
SKCM	Claudin-7 →	+0.300	+2.841	<.001	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Acetyl-a-Tubulin-Lys40 by BPIFB6 expression — UCEC

Explore this box plot interactively →