Across TCGA cell cohorts, BPIFB3 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BPIFB3-associated genes across cancer lineages are DEFB108B, ACSM2A, and SMIM9. Each is linked with BPIFB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BPIFB3-to-partner and partner-to-BPIFB3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPIFB3→partner) and Y-score (partner→BPIFB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DEFB108B →	+0.144	+5.684	<.001	<.001	3	2
PANCREAS	ACSM2A →	+0.022	+5.000	<.001	.006	3	1
PANCREAS	SMIM9 →	+0.036	+5.614	<.001	.002	3	1
PANCREAS	GPX5 →	+0.033	+5.000	<.001	.006	3	1
PANCREAS	KRTAP4-2 →	+0.045	+5.000	<.001	.006	3	1
BLOOD_Leukemia	ASB10 →	+0.125	+3.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

BPIFB3 survival (RNA) · tumor vs normal (RNA) · all BPIFB3 data types