Across TCGA pan-cancer cohorts, BPIFB3 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of BPIFB3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where BPIFB3 RNA is repressed in tumor relative to normal tissue. In most cancer types BPIFB3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, LUSC, and LUAD are the cancer types where BPIFB3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BPIFB3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.041	.005	5	view →
LUSC	All	All	+0.027	.012	2	view →
LUAD	Male	All	+0.015	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: BPIFB3 RNA expression & survival · all BPIFB3 data types