BPIFA3

Across TCGA patient cohorts, BPIFA3 mutation is significantly associated with the RNA expression of many other genes, with 1,221 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPIFA3-associated genes across cancer lineages are RNA5SP412, CDK5, and NDUFB6. Each is linked with BPIFA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BPIFA3-to-partner and partner-to-BPIFA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by BPIFA3-low versus BPIFA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPIFA3→partner) and Y-score (partner→BPIFA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.756	+2.382	<.001	.003	3	2
SKCM	CDK5 →	+0.536	+2.732	.002	.003	3	2
SKCM	NDUFB6 →	+0.533	+3.484	.001	.002	3	2
SKCM	TOMM5 →	+0.460	+3.506	.001	.002	3	2
SKCM	OR6C69P →	+0.105	+2.328	<.001	.007	3	2
UCEC	EME1 →	+0.588	+3.212	.008	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,221 associations by consensus.

RNA5SP412 by BPIFA3 expression — UCEC

Explore this box plot interactively →