BPIFA3

Across TCGA patient cohorts, BPIFA3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPIFA3-associated genes across cancer lineages are Akt_pT308, MSH2, and Myosin-IIa_pS1943. Each is linked with BPIFA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BPIFA3-to-partner and partner-to-BPIFA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by BPIFA3-low versus BPIFA3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPIFA3→partner) and Y-score (partner→BPIFA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Akt_pT308 →	+0.558	+2.321	.025	.035	3	2
UCEC	MSH2 →	-0.280	-2.973	.012	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.225	+2.472	.024	.011	3	1
UCEC	Notch1 →	+0.254	+2.459	<.001	.020	3	1
UCEC	p62 Lck ligand →	+0.418	+3.169	.007	.018	3	1
UCEC	Rab25 →	-0.529	-3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Akt_pT308 by BPIFA3 expression — SKCM

Explore this box plot interactively →