Across TCGA pan-cancer cohorts, BPIFA1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated BPIFA1 data layer compared with 14 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher BPIFA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated BPIFA1 expression acts as an unfavorable survival marker.

UCEC, LSCC, and HNSC are the cancer types where BPIFA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.159	1.000	.038	8	view →
LSCC	DFS	Quartile	II,III,IV	0.815	0.978	.036	3	view →
HNSC	OS	Median	III,IV	0.552	0.752	.041	2	view →
LUAD	OS	Quartile	All	0.762	1.000	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: BPIFA1 tumor-vs-normal RNA expression · all BPIFA1 data types