Across TCGA pan-cancer cohorts, BPIFA1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of BPIFA1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where BPIFA1 RNA is repressed in tumor relative to normal tissue. In most cancer types BPIFA1 is over-expressed in tumor, although a few such as LUSC and HNSC show the opposite, repressed pattern.

LUSC, HNSC, and LUAD are the cancer types where BPIFA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BPIFA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	−2.316	.028	4	view →
HNSC	Male	All	−1.771	.002	4	view →
LUAD	All	All	+1.648	.008	4	view →
THCA	Male	All	+0.105	.001	3	view →
LUSC	Female	III,IV	+5.775	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 4 lineages.

Exploration

Same gene, other analysis: BPIFA1 RNA expression & survival · all BPIFA1 data types