BPIFA1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, BPIFA1 mutation is significantly associated with the RNA expression of many other genes, with 1,067 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPIFA1-associated genes across cancer lineages are PRSS53, DFFB, and OTUD3. Each is linked with BPIFA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BPIFA1-to-partner and partner-to-BPIFA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPIFA1→partner) and Y-score (partner→BPIFA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECPRSS53 →+0.355+3.981<.001<.00132
UCECDFFB →+0.549+3.332.001.00532
UCECOTUD3 →+0.692+2.818<.001.00132
UCECZWILCH →+0.520+2.601.008.00632
UCECZNF77 →+0.524+2.601.001.00632
UCECTCF3 →+0.629+2.828.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,067 associations by consensus.

Exploration