Across TCGA patient cohorts, BPIFA1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPIFA1-associated genes across cancer lineages are Notch1, p62 Lck ligand, and 14-3-3_beta. Each is linked with BPIFA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BPIFA1-to-partner and partner-to-BPIFA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPIFA1→partner) and Y-score (partner→BPIFA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.147	+2.817	.037	.036	3	2
UCEC	p62 Lck ligand →	+0.394	+3.179	.016	.010	3	2
UCEC	14-3-3_beta →	-0.151	-3.149	.002	.019	3	1
UCEC	MEK1 →	+0.495	+3.169	.007	.019	3	1
UCEC	N-Ras →	-0.156	-3.446	.009	.005	3	1
UCEC	p90 RSK_pT359_S363 →	-0.229	-2.321	.024	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

BPIFA1 survival (RNA) · tumor vs normal (RNA) · all BPIFA1 data types