BPI

Across TCGA cell cohorts, BPI mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible BPI-associated genes across cancer lineages are SPRR4, OR2T7, and SPRR5. Each is linked with BPI in more than 1 cancer types. Because this analysis shows association rather than direction, both BPI-to-partner and partner-to-BPI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRR4 grouped by BPI-low versus BPI-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPI→partner) and Y-score (partner→BPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPRR4 →	+0.076	+5.643	<.001	.002	3	1
LUNG_SCLC	OR2T7 →	+0.006	+5.643	<.001	.002	3	1
LUNG_SCLC	SPRR5 →	+0.470	+5.643	<.001	.002	3	1
LUNG_NSCLC_LUAD	ASZ1 →	+0.428	+4.157	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR10G7 →	+0.009	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	FAM162B →	+0.270	+4.050	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

SPRR4 by BPI expression — LUNG_SCLC

Explore this box plot interactively →