BPHL

Across TCGA patient cohorts, BPHL mutation is significantly associated with the RNA expression of many other genes, with 363 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPHL-associated genes across cancer lineages are RN7SL794P, PGBD4P8, and LINC01789. Each is linked with BPHL in more than 1 cancer types. Because this analysis shows association rather than direction, both BPHL-to-partner and partner-to-BPHL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL794P grouped by BPHL-low versus BPHL-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPHL→partner) and Y-score (partner→BPHL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL794P →	+0.310	+4.268	<.001	.008	3	2
SKCM	PGBD4P8 →	+0.117	+4.513	<.001	.009	3	2
SKCM	LINC01789 →	+0.050	+4.324	.008	.007	3	2
BLCA	MIR874 →	+0.520	+5.266	<.001	.001	3	1
BLCA	RPLP1P10 →	+0.130	+4.497	<.001	.009	3	1
BLCA	LINC00376 →	+0.179	+4.642	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 363 associations by consensus.

RN7SL794P by BPHL expression — BLCA

Explore this box plot interactively →