BPGM

Across TCGA pan-cancer cohorts, BPGM mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated BPGM data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher BPGM mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BPGM expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where BPGM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.969	0.722	.001	41	view →
CCRCC	DFS	Median	All	0.868	0.628	.002	17	view →
LUAD	DFS	Tertile	III,IV	0.408	0.920	.013	8	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

BPGM–HNSC (OS)

Open the HNSC breakdown →