BPGM

Across TCGA pan-cancer cohorts, BPGM RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of BPGM’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BPGM RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BPGM is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

HNSC, LIHC, and BLCA are the cancer types where BPGM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BPGM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.711	<.001	12	view →
LIHC	Female	All	+1.230	<.001	9	view →
BLCA	All	All	+0.890	.002	7	view →
BRCA	All	II,III,IV	+0.417	<.001	6	view →
KIRC	All	II,III,IV	−0.341	.001	6	view →
CHOL	Female	All	+2.390	<.001	5	view →
THCA	All	All	+0.245	.001	5	view →
LUAD	All	All	+0.279	.001	4	view →
UCEC	All	All	+0.619	.001	2	view →
LUSC	Male	All	+0.352	.015	2	view →
KICH	Male	All	+0.667	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

BPGM–HNSC

Open the HNSC breakdown →