BPGM

Across TCGA patient cohorts, BPGM mutation is significantly associated with the RNA expression of many other genes, with 2,825 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPGM-associated genes across cancer lineages are RNA5SP419, RNA5SP413, and BTBD10. Each is linked with BPGM in more than 1 cancer types. Because this analysis shows association rather than direction, both BPGM-to-partner and partner-to-BPGM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP419 grouped by BPGM-low versus BPGM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPGM→partner) and Y-score (partner→BPGM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP419 →	+0.593	+1.989	<.001	.002	3	2
LUSC	RNA5SP413 →	+1.927	+6.081	<.001	.002	3	2
UCEC	BTBD10 →	+0.440	+3.617	.002	.001	3	1
UCEC	LIN7C →	+0.637	+2.413	<.001	<.001	3	1
UCEC	IMMP1L →	+0.367	+2.254	.003	.005	3	1
UCEC	PGAP2 →	+0.446	+2.885	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,825 associations by consensus.

RNA5SP419 by BPGM expression — UCEC

Explore this box plot interactively →