BPGM

Across TCGA patient cohorts, BPGM mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BPGM-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and eIF4G. Each is linked with BPGM in more than 1 cancer types. Because this analysis shows association rather than direction, both BPGM-to-partner and partner-to-BPGM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by BPGM-low versus BPGM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BPGM→partner) and Y-score (partner→BPGM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.250	-2.222	.019	.011	3	1
UCEC	eIF4E →	+0.191	+2.222	.032	.011	3	1
UCEC	eIF4G →	+0.260	+1.700	.048	.044	3	1
UCEC	ACC1 →	+0.359	+3.013	.020	.018	3	1
UCEC	JNK2 →	+0.234	+3.469	.005	.002	3	1
UCEC	Notch1 →	+0.157	+1.700	.008	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by BPGM expression — UCEC

Explore this box plot interactively →