BORCS5

Across TCGA pan-cancer cohorts, BORCS5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated BORCS5 data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher BORCS5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BORCS5 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where BORCS5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.914	0.684	.001	35	view →
PDAC	OS	Quartile	II,III,IV	1.000	0.616	<.001	19	view →
LUAD	DFS	Median	II,III,IV	0.767	0.939	.002	10	view →
UCEC	DFS	Tertile	All	0.931	1.000	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

BORCS5–LSCC (DFS)

Open the LSCC breakdown →