BORCS5

Across TCGA pan-cancer cohorts, BORCS5 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of BORCS5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where BORCS5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BORCS5 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

COAD, LIHC, and HNSC are the cancer types where BORCS5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BORCS5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.677	<.001	11	view →
LIHC	All	III,IV	+0.773	<.001	9	view →
HNSC	All	All	+0.456	<.001	8	view →
KIRC	All	All	−0.188	<.001	7	view →
LUSC	Male	All	+0.732	<.001	6	view →
LUAD	Male	All	+0.456	<.001	5	view →
CHOL	Female	All	+1.666	<.001	3	view →
READ	All	All	+0.491	.003	3	view →
THCA	All	All	−0.210	<.001	3	view →
KIRP	All	II,III,IV	+0.331	.036	1	view →
KICH	All	All	−0.282	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

BORCS5–COAD

Open the COAD breakdown →