BOLL

Across TCGA patient cohorts, BOLL mutation is significantly associated with the RNA expression of many other genes, with 1,704 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BOLL-associated genes across cancer lineages are MIR8053, RNU6-15P, and E2F6P1. Each is linked with BOLL in more than 2 cancer types. Because this analysis shows association rather than direction, both BOLL-to-partner and partner-to-BOLL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8053 grouped by BOLL-low versus BOLL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BOLL→partner) and Y-score (partner→BOLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR8053 →	+0.261	+4.399	<.001	.006	3	3
SKCM	RNU6-15P →	+0.393	+3.738	<.001	<.001	3	3
SKCM	E2F6P1 →	+0.022	+3.009	<.001	.009	3	2
SKCM	SNORD62A →	+0.502	+3.168	.003	<.001	3	2
UCEC	ZDHHC7 →	+0.393	+2.724	.001	.003	3	2
UCEC	ZC3H18 →	+0.429	+1.871	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,704 associations by consensus.

MIR8053 by BOLL expression — COAD

Explore this box plot interactively →