BOLL

Across TCGA pan-cancer cohorts, BOLL RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of BOLL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BOLL RNA is repressed in tumor relative to normal tissue. In most cancer types BOLL is over-expressed in tumor, although a few such as KIRC and STAD show the opposite, repressed pattern.

KIRC, LUSC, and UCEC are the cancer types where BOLL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BOLL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.032	.001	8	view →
LUSC	Female	All	+0.086	<.001	6	view →
UCEC	All	All	+0.051	.002	6	view →
STAD	All	All	+0.213	.009	5	view →
BLCA	All	All	+0.085	.014	3	view →
LUAD	All	All	+0.111	.008	2	view →
STAD	Male	IV	−0.155	.001	1	view →
HNSC	Male	All	−0.135	.025	1	view →
LIHC	All	All	+0.007	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 8 lineages.

BOLL–KIRC

Open the KIRC breakdown →