BOLL

Across TCGA patient cohorts, BOLL mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BOLL-associated genes across cancer lineages are Annexin-1, Caspase-8, and EGFR_pY1068. Each is linked with BOLL in more than 1 cancer types. Because this analysis shows association rather than direction, both BOLL-to-partner and partner-to-BOLL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by BOLL-low versus BOLL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BOLL→partner) and Y-score (partner→BOLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.708	+2.720	<.001	.003	3	2
UCEC	Caspase-8 →	-0.233	-2.089	.015	.016	3	2
UCEC	EGFR_pY1068 →	-0.198	-1.678	.040	.023	3	1
UCEC	MEK1 →	+0.369	+1.678	.008	.023	3	1
UCEC	MSH2 →	-0.189	-3.295	.033	.009	3	1
UCEC	p62 Lck ligand →	+0.320	+2.594	.010	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Annexin-1 by BOLL expression — UCEC

Explore this box plot interactively →