BOLL

Across TCGA cell cohorts, BOLL mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible BOLL-associated genes across cancer lineages are NUPR2, AVP, and KRT71. Each is linked with BOLL in more than 1 cancer types. Because this analysis shows association rather than direction, both BOLL-to-partner and partner-to-BOLL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUPR2 grouped by BOLL-low versus BOLL-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BOLL→partner) and Y-score (partner→BOLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NUPR2 →	+0.065	+4.539	<.001	.007	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRT71 →	+0.013	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.162	+4.867	<.001	.009	3	1
BLOOD_Leukemia	MYOCD →	+0.858	+4.108	.006	.009	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

NUPR2 by BOLL expression — BLOOD_Leukemia

Explore this box plot interactively →