BOLA2-SMG1P6

Across TCGA pan-cancer cohorts, BOLA2-SMG1P6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of BOLA2-SMG1P6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BOLA2-SMG1P6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BOLA2-SMG1P6 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, LIHC, and LUSC are the cancer types where BOLA2-SMG1P6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BOLA2-SMG1P6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.913	<.001	12	view →
LIHC	Male	III,IV	+0.780	<.001	9	view →
LUSC	Male	All	+1.092	<.001	8	view →
BLCA	Male	All	+1.004	<.001	8	view →
LUAD	Male	All	+0.860	<.001	8	view →
KIRP	All	II,III,IV	+0.588	<.001	8	view →
THCA	All	All	−0.323	<.001	8	view →
BRCA	All	All	+0.674	<.001	6	view →
STAD	All	II,III,IV	+0.604	<.001	6	view →
CHOL	All	All	+1.514	<.001	5	view →
ESCA	All	All	+0.757	.003	2	view →
COAD	Female	III,IV	+0.422	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

BOLA2-SMG1P6–HNSC

Open the HNSC breakdown →