BOK

Across TCGA pan-cancer cohorts, BOK mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated BOK data layer compared with 22 for mass-spec protein.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher BOK mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated BOK expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where BOK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.272	0.564	.001	23	view →
LUAD	DFS	Quartile	All	0.832	0.537	.011	3	view →
CCRCC	OS	Quartile	II,III,IV	0.818	1.000	.043	2	view →
LSCC	DFS	Median	III,IV	0.463	0.896	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

BOK–PDAC (OS)

Open the PDAC breakdown →