BOK

Across TCGA patient cohorts, BOK mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BOK-associated genes across cancer lineages are eEF2, GATA6, and Ku80. Each is linked with BOK in more than 1 cancer types. Because this analysis shows association rather than direction, both BOK-to-partner and partner-to-BOK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by BOK-low versus BOK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BOK→partner) and Y-score (partner→BOK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.595	+3.169	.002	.020	3	1
UCEC	GATA6 →	-0.225	-3.000	.008	.035	3	1
UCEC	Ku80 →	+0.276	+3.183	.033	.010	3	1
UCEC	p70-S6K_pT389 →	-0.267	-3.169	.010	.020	3	1
UCEC	Rab25 →	-0.545	-3.169	.002	.020	3	1
UCEC	AR →	-0.469	-3.169	.022	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eEF2 by BOK expression — UCEC

Explore this box plot interactively →