BOK

Across TCGA cell cohorts, BOK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,663 significant associations in total. BONE shows the largest number of these associations.

The most reproducible BOK-associated GO terms across cancer lineages are Regulation of chorionic trophoblast cell proliferation, Actin filament bundle assembly, and Regulation of execution phase of apoptosis. Each is linked with BOK in more than 18 cancer types. Because this analysis shows association rather than direction, both BOK-to-partner and partner-to-BOK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chorionic trophoblast cell proliferation grouped by BOK-low versus BOK-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BOK→partner) and Y-score (partner→BOK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of chorionic trophoblast cell proliferation →	+1.535	+2.558	<.001	<.001	3	19
KIDNEY	Actin filament bundle assembly →	+0.095	+1.154	<.001	.005	3	10
LIVER	Regulation of execution phase of apoptosis →	+0.133	+1.179	<.001	.002	3	10
LIVER	Positive regulation of execution phase of apoptosis →	+0.140	+1.153	<.001	.003	3	10
BLOOD_Leukemia	Metaphase/anaphase transition of cell cycle →	+0.063	+0.210	<.001	<.001	3	10
SOFT_TISSUE	Positive regulation of neuromuscular junction development →	+0.146	+0.939	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,663 associations by consensus.

Regulation of chorionic trophoblast cell proliferation by BOK expression — STOMACH

Explore this box plot interactively →