BOK-AS1

Across TCGA pan-cancer cohorts, BOK-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of BOK-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where BOK-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types BOK-AS1 is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

LUSC, BRCA, and LUAD are the cancer types where BOK-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BOK-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	III,IV	−0.955	<.001	8	view →
BRCA	All	III,IV	−1.210	<.001	6	view →
LUAD	Female	All	−0.430	<.001	6	view →
COAD	All	All	+0.966	.001	5	view →
THCA	All	All	−0.093	<.001	5	view →
HNSC	All	All	+0.473	.014	4	view →
KICH	All	All	−0.174	.005	4	view →
STAD	Male	IV	+3.895	.004	3	view →
LIHC	Female	All	−0.712	<.001	2	view →
CHOL	All	All	−0.694	.014	2	view →
PRAD	All	All	−0.076	.021	2	view →
KIRC	All	IV	+0.086	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

BOK-AS1–LUSC

Open the LUSC breakdown →