BOC

Across TCGA cell cohorts, BOC mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BOC-associated genes across cancer lineages are C9orf72, OLIG3, and PDHA2. Each is linked with BOC in more than 1 cancer types. Because this analysis shows association rather than direction, both BOC-to-partner and partner-to-BOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf72 grouped by BOC-low versus BOC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BOC→partner) and Y-score (partner→BOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C9orf72 →	+0.640	+2.628	.006	.002	3	2
PANCREAS	OLIG3 →	+0.006	+5.000	<.001	.006	3	1
SOFT_TISSUE	PDHA2 →	+0.033	+5.977	<.001	.001	3	1
SKIN	CSN1S1 →	+0.627	+3.684	<.001	.006	3	1
SKIN	BPIFB3 →	+0.018	+4.437	<.001	.004	3	1
SKIN	PPP3R2 →	+0.017	+4.459	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

C9orf72 by BOC expression — LARGE_INTESTINE

Explore this box plot interactively →