BOC

Across TCGA pan-cancer cohorts, BOC RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of BOC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where BOC RNA is repressed in tumor relative to normal tissue. In most cancer types BOC is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, HNSC, and BLCA are the cancer types where BOC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BOC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−2.093	<.001	11	view →
HNSC	Male	All	−1.407	<.001	11	view →
BLCA	Male	III,IV	−2.961	<.001	8	view →
LIHC	All	All	+0.260	<.001	8	view →
THCA	All	All	−0.600	.001	7	view →
UCEC	All	III,IV	−3.084	<.001	6	view →
BRCA	All	III,IV	−1.925	<.001	6	view →
KIRP	Male	All	−1.180	<.001	6	view →
COAD	All	II,III,IV	−0.760	.001	6	view →
STAD	Female	All	−1.778	.011	3	view →
READ	All	All	−1.686	.002	2	view →
PRAD	All	All	−0.441	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

BOC–KICH

Open the KICH breakdown →