BNIP3P40

Across TCGA pan-cancer cohorts, BNIP3P40 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated BNIP3P40 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher BNIP3P40 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BNIP3P40 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LAML show a favorable association.

KIRC, THCA, and MESO are the cancer types where BNIP3P40 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	II,III,IV	0.414	0.664	.003	106	view →
THCA	OS	Median	All	0.978	1.000	<.001	59	view →
MESO	DFS	Median	II,III,IV	0.228	0.672	<.001	58	view →
BRCA	DFS	Tertile	All	0.917	0.870	.009	43	view →
ACC	DFS	Median	All	0.379	0.706	.007	41	view →
LAML	DFS	Tertile	All	0.551	0.324	.004	38	view →
CHOL	DFS	Tertile	II,III,IV	0.125	0.562	.004	34	view →
HNSC	OS	Median	II,III,IV	0.831	0.708	.004	30	view →
KICH	DFS	Quartile	III,IV	0.047	0.849	.001	21	view →
THYM	DFS	Median	All	0.788	0.929	.004	20	view →
KIRP	OS	Quartile	II,III,IV	0.209	0.721	.003	20	view →
STAD	OS	Tertile	IV	0.877	0.314	.015	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

BNIP3P40–KIRC (DFS)

Open the KIRC breakdown →