BNIP3P40

Across TCGA pan-cancer cohorts, BNIP3P40 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of BNIP3P40’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where BNIP3P40 RNA is repressed in tumor relative to normal tissue. In most cancer types BNIP3P40 is over-expressed in tumor, although a few such as THCA and STAD show the opposite, repressed pattern.

THCA, BLCA, and STAD are the cancer types where BNIP3P40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BNIP3P40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.133	.001	3	view →
BLCA	All	All	+0.264	.029	2	view →
STAD	All	IV	−0.263	.001	2	view →
BRCA	All	II,III,IV	+0.223	.040	2	view →
ESCA	Female	All	−0.339	.024	1	view →
HNSC	Female	III,IV	−0.083	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

BNIP3P40–THCA

Open the THCA breakdown →