Across TCGA pan-cancer cohorts, BNIP3P31 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of BNIP3P31’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where BNIP3P31 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BNIP3P31 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
BRCA and KIRC are the cancer types where BNIP3P31 tumor–normal differential expression is most reproducible.