BNIP3

Across TCGA patient cohorts, BNIP3 protein abundance is significantly associated with the RNA expression of many other genes, with 10,184 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BNIP3-associated genes across cancer lineages are DCN, RFTN1, and PPFIA4. Each is linked with BNIP3 in more than 4 cancer types. Because this analysis shows association rather than direction, both BNIP3-to-partner and partner-to-BNIP3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BNIP3 versus DCN in CCRCC, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BNIP3→partner) and Y-score (partner→BNIP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DCN →	-1.471	-0.367	.002	.003	3	4
BRCA	RFTN1 →	-0.705	-0.909	<.001	<.001	3	4
LSCC	PPFIA4 →	+1.184	+0.661	<.001	<.001	3	4
UCEC	TBC1D2B →	-0.430	-0.465	.005	.007	3	4
CCRCC	SYNPO2 →	-1.230	-0.456	<.001	<.001	3	4
UCEC	GAS1 →	-1.325	-0.684	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,184 associations by consensus.

BNIP3 vs DCN — CCRCC

Explore this scatter interactively →