BNC2

Across TCGA patient cohorts, BNC2 mutation is significantly associated with the RNA expression of many other genes, with 6,872 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BNC2-associated genes across cancer lineages are LIG1, ERI1, and DCTN6. Each is linked with BNC2 in more than 4 cancer types. Because this analysis shows association rather than direction, both BNC2-to-partner and partner-to-BNC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIG1 grouped by BNC2-low versus BNC2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BNC2→partner) and Y-score (partner→BNC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LIG1 →	+0.447	+3.999	.003	<.001	3	5
COAD	ERI1 →	+0.484	+1.887	<.001	.001	3	4
COAD	DCTN6 →	+0.379	+2.512	.003	<.001	3	4
STAD	BNIP3L →	+0.671	+3.733	<.001	<.001	3	4
LUAD	UBE2S →	+0.732	+3.482	.002	.002	2	5
UCEC	FOXM1 →	+0.645	+1.780	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,872 associations by consensus.

LIG1 by BNC2 expression — LUAD

Explore this box plot interactively →