BNC2

Across TCGA pan-cancer cohorts, BNC2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated BNC2 data layer compared with 12 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher BNC2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated BNC2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

UVM, HNSC, and UCS are the cancer types where BNC2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	III,IV	0.395	0.903	.001	73	view →
HNSC	DFS	Quartile	III,IV	0.661	0.450	.003	46	view →
UCS	OS	Quartile	II,III,IV	0.755	0.210	.004	34	view →
LUAD	DFS	Tertile	IV	0.593	0.969	.008	28	view →
UCEC	OS	Median	All	0.903	0.948	.004	26	view →
BLCA	OS	Tertile	All	0.372	0.628	.003	25	view →
DLBC	DFS	Median	III,IV	1.000	0.525	.013	18	view →
ESCA	OS	Quartile	II,III,IV	0.718	0.428	.018	17	view →
STAD	OS	Quartile	All	0.515	0.650	.032	13	view →
THCA	DFS	Median	All	0.921	0.867	.021	10	view →
CHOL	DFS	Tertile	All	0.706	0.312	.026	9	view →
SARC	DFS	Tertile	All	0.394	0.629	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

BNC2–UVM (OS)

Open the UVM breakdown →