BNC2

Across TCGA patient cohorts, BNC2 mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BNC2-associated genes across cancer lineages are PDCD4, ASNS, and PKC-b-II_pS660. Each is linked with BNC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both BNC2-to-partner and partner-to-BNC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by BNC2-low versus BNC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BNC2→partner) and Y-score (partner→BNC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.513	-1.469	<.001	<.001	3	4
UCEC	ASNS →	+0.384	+2.000	<.001	<.001	3	4
COAD	PKC-b-II_pS660 →	-0.374	-1.839	.001	.008	3	4
STAD	INPP4B →	+0.563	+3.700	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.658	+2.263	<.001	<.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.395	-1.308	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

PDCD4 by BNC2 expression — UCEC

Explore this box plot interactively →