BNC2

Across TCGA cell cohorts, BNC2 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible BNC2-associated genes across cancer lineages are CCL21, CPXCR1, and ARSH. Each is linked with BNC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BNC2-to-partner and partner-to-BNC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL21 grouped by BNC2-low versus BNC2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BNC2→partner) and Y-score (partner→BNC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CCL21 →	+0.043	+3.256	<.001	.005	3	2
LUNG_SCLC	CPXCR1 →	+0.024	+3.070	.005	.009	3	2
BLOOD_Leukemia	ARSH →	+0.007	+3.922	<.001	.002	3	2
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
LUNG_SCLC	NPVF →	+0.022	+3.256	<.001	.005	3	1
LUNG_SCLC	S100A12 →	+0.151	+3.491	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

CCL21 by BNC2 expression — LUNG_SCLC

Explore this box plot interactively →