BNC1

Across TCGA patient cohorts, BNC1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BNC1-associated genes across cancer lineages are FASN, Caspase-7-cleavedD198, and Tuberin. Each is linked with BNC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BNC1-to-partner and partner-to-BNC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by BNC1-low versus BNC1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BNC1→partner) and Y-score (partner→BNC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FASN →	+0.612	+3.185	.002	.009	3	3
COAD	Caspase-7-cleavedD198 →	+1.349	+3.016	<.001	.018	3	3
UCEC	Tuberin →	+0.488	+2.874	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.309	+2.730	.001	.003	3	3
LUAD	Chk1 →	+0.327	+3.000	.005	.035	3	2
STAD	p90 RSK_pT359_S363 →	-0.256	-3.169	.008	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

FASN by BNC1 expression — STAD

Explore this box plot interactively →