BNC1

Across TCGA pan-cancer cohorts, BNC1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated BNC1 data layer compared with 10 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher BNC1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BNC1 expression acts as an unfavorable survival marker, although some lineages such as THCA and BRCA show a favorable association.

UVM, KIRC, and OV are the cancer types where BNC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.591	0.854	<.001	87	view →
KIRC	DFS	Quartile	II,III,IV	0.660	0.927	<.001	75	view →
OV	DFS	Tertile	All	0.300	0.421	<.001	72	view →
UCEC	DFS	Median	All	0.785	0.876	.001	50	view →
THCA	DFS	Quartile	All	0.971	0.623	.004	49	view →
BRCA	DFS	Median	III,IV	0.603	0.285	.001	43	view →
LAML	DFS	Median	All	0.505	0.256	<.001	40	view →
SKCM	OS	Median	All	0.829	0.910	.001	38	view →
LUAD	OS	Quartile	III,IV	0.472	0.706	.016	30	view →
STAD	DFS	Quartile	All	0.473	0.652	.006	26	view →
BLCA	DFS	Quartile	II,III,IV	0.314	0.424	.007	22	view →
KICH	OS	Quartile	All	1.000	0.626	.020	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

BNC1–UVM (DFS)

Open the UVM breakdown →