BMPR1B-DT

Across TCGA pan-cancer cohorts, BMPR1B-DT RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of BMPR1B-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BMPR1B-DT RNA is repressed in tumor relative to normal tissue. In most cancer types BMPR1B-DT is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where BMPR1B-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BMPR1B-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.217	<.001	12	view →
KIRP	Male	II,III,IV	−2.104	<.001	11	view →
KICH	Male	IV	−2.540	<.001	10	view →
LUSC	Male	III,IV	−0.940	<.001	7	view →
LUAD	All	III,IV	−0.474	.012	7	view →
THCA	Male	All	−0.167	<.001	7	view →
BRCA	All	III,IV	+2.443	<.001	6	view →
HNSC	Male	IV	+0.152	.032	4	view →
COAD	Male	II,III,IV	−0.136	.011	4	view →
UCEC	All	All	+1.613	.021	2	view →
PRAD	All	All	+0.720	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

BMPR1B-DT–KIRC

Open the KIRC breakdown →