BMPER

Across TCGA pan-cancer cohorts, BMPER Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated BMPER data layer compared with 27 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher BMPER Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated BMPER expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

ESCA, UCEC, and LUAD are the cancer types where BMPER Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.074	0.703	<.001	36	view →
UCEC	DFS	Median	II,III,IV	0.933	0.432	.011	28	view →
LUAD	DFS	Median	IV	0.045	0.717	<.001	20	view →
LIHC	DFS	Median	II,III,IV	0.044	0.414	<.001	13	view →
KIRP	OS	Median	All	0.272	0.885	<.001	12	view →
DLBC	OS	Median	II,III,IV	0.118	0.802	.025	12	view →
PRAD	DFS	Median	All	0.617	0.886	.011	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
GBM	DFS	Median	All	0.031	0.243	<.001	3	view →
STAD	DFS	Median	All	0.106	0.492	.007	3	view →
SKCM	OS	Median	II,III,IV	0.597	0.360	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

BMPER–ESCA (OS)

Open the ESCA breakdown →