BMP8B

Across TCGA patient cohorts, BMP8B mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMP8B-associated genes across cancer lineages are OR10Z1, MIR549A, and RNU6-380P. Each is linked with BMP8B in more than 1 cancer types. Because this analysis shows association rather than direction, both BMP8B-to-partner and partner-to-BMP8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10Z1 grouped by BMP8B-low versus BMP8B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP8B→partner) and Y-score (partner→BMP8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR10Z1 →	+0.096	+7.307	<.001	<.001	3	2
BLCA	MIR549A →	+0.481	+6.147	<.001	.002	3	2
UCEC	RNU6-380P →	+0.260	+4.885	<.001	.002	3	2
UCEC	RNU6-693P →	+0.165	+4.137	.007	.008	3	2
UCEC	RN7SL134P →	+0.203	+4.336	<.001	<.001	3	2
SKCM	RNU7-8P →	+0.641	+5.680	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

OR10Z1 by BMP8B expression — BLCA

Explore this box plot interactively →