BMP8B

Across TCGA cell cohorts, BMP8B mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible BMP8B-associated genes across cancer lineages are SCGB2A1, OTOS, and MRAP. Each is linked with BMP8B in more than 1 cancer types. Because this analysis shows association rather than direction, both BMP8B-to-partner and partner-to-BMP8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB2A1 grouped by BMP8B-low versus BMP8B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP8B→partner) and Y-score (partner→BMP8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SCGB2A1 →	+0.061	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OTOS →	+0.052	+5.969	<.001	.001	3	1
SKIN	MRAP →	+0.026	+4.930	.001	.001	3	1
SKIN	OR6C70 →	+0.084	+5.217	<.001	<.001	3	1
SKIN	KRT73 →	+0.030	+4.467	<.001	.004	3	1
SKIN	DPEP2NB →	+0.030	+4.273	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SCGB2A1 by BMP8B expression — BLOOD_Leukemia

Explore this box plot interactively →