BMP3

Across TCGA pan-cancer cohorts, BMP3 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated BMP3 data layer compared with 18 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher BMP3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated BMP3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, ESCA, and SCLC are the cancer types where BMP3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.181	0.768	<.001	24	view →
ESCA	OS	Median	All	0.198	0.872	.003	18	view →
SCLC	OS	Median	II,III,IV	0.082	0.648	<.001	18	view →
LGG	DFS	Median	All	0.230	0.753	.005	12	view →
CESC	DFS	Median	II,III,IV	0.146	0.705	.010	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
UCEC	DFS	Median	All	0.941	0.624	.022	6	view →
GBM	DFS	Median	All	0.066	0.242	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

BMP3–HNSC (OS)

Open the HNSC breakdown →