BMP3

Across TCGA pan-cancer cohorts, BMP3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of BMP3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where BMP3 RNA is repressed in tumor relative to normal tissue. In most cancer types BMP3 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and HNSC are the cancer types where BMP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BMP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−4.399	<.001	12	view →
LUSC	All	III,IV	−2.971	<.001	9	view →
HNSC	All	III,IV	−1.081	.001	9	view →
KIRC	All	III,IV	−0.350	.001	9	view →
READ	Male	All	−4.603	<.001	7	view →
STAD	All	II,III,IV	−1.720	<.001	7	view →
LUAD	Male	II,III,IV	−1.928	<.001	6	view →
BRCA	All	III,IV	−0.998	<.001	6	view →
THCA	All	III,IV	−0.199	.003	6	view →
UCEC	All	II,III,IV	−0.890	.049	2	view →
KIRP	Male	All	−0.224	<.001	2	view →
ESCA	All	All	−0.652	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

BMP3–COAD

Open the COAD breakdown →