BMP2K

Across TCGA cell cohorts, BMP2K mutation is significantly associated with the RNA expression of many other genes, with 359 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BMP2K-associated genes across cancer lineages are GAGE12J, ETDC, and TEX51. Each is linked with BMP2K in more than 1 cancer types. Because this analysis shows association rather than direction, both BMP2K-to-partner and partner-to-BMP2K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12J grouped by BMP2K-low versus BMP2K-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP2K→partner) and Y-score (partner→BMP2K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ETDC →	+0.593	+4.643	<.001	.008	3	1
BLOOD_Lymphoma	TEX51 →	+0.026	+5.643	<.001	.002	3	1
LARGE_INTESTINE	TBL2 →	+0.513	+3.212	.004	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.121	+3.295	.002	.006	3	1
LARGE_INTESTINE	C1QBP →	+0.797	+3.299	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 359 associations by consensus.

GAGE12J by BMP2K expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →