BMP1

Across TCGA cell cohorts, BMP1 mutation is significantly associated with the RNA expression of many other genes, with 288 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BMP1-associated genes across cancer lineages are MTRNR2L5, LGI3, and GNG8. Each is linked with BMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BMP1-to-partner and partner-to-BMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L5 grouped by BMP1-low versus BMP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP1→partner) and Y-score (partner→BMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MTRNR2L5 →	+0.020	+4.984	<.001	.002	3	2
LARGE_INTESTINE	LGI3 →	+0.240	+3.392	.003	.003	3	2
CNS	GNG8 →	+1.075	+3.643	<.001	.007	3	2
BLOOD_Leukemia	PAX1 →	+0.042	+4.060	<.001	.003	3	1
BLOOD_Leukemia	RHCG →	+0.103	+3.729	<.001	.009	3	1
BLOOD_Leukemia	DIRAS2 →	+0.126	+4.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 288 associations by consensus.

MTRNR2L5 by BMP1 expression — BLOOD_Leukemia

Explore this box plot interactively →