BMP1

Across TCGA pan-cancer cohorts, BMP1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated BMP1 data layer compared with 10 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher BMP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated BMP1 expression acts as an unfavorable survival marker, although some lineages such as DLBC and THCA show a favorable association.

KIRC, ACC, and MESO are the cancer types where BMP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.550	0.701	<.001	123	view →
ACC	DFS	Median	All	0.204	0.695	<.001	101	view →
MESO	DFS	Quartile	All	0.248	0.569	<.001	87	view →
LGG	DFS	Median	All	0.637	0.844	<.001	54	view →
UVM	OS	Tertile	All	0.484	0.834	.001	38	view →
LUAD	DFS	Quartile	All	0.711	0.837	.002	30	view →
UCS	DFS	Tertile	IV	0.239	0.793	.024	24	view →
BLCA	DFS	Median	All	0.213	0.452	.002	23	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	21	view →
DLBC	OS	Tertile	III,IV	1.000	0.154	.008	20	view →
THCA	DFS	Tertile	All	0.895	0.489	.012	15	view →
PAAD	DFS	Median	All	0.209	0.354	.022	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

BMP1–KIRC (OS)

Open the KIRC breakdown →